Edmund Lam
Home
Biography
CV
Research
Group
Publications
Opportunities
Students
Teaching
ELEC2844
ELEC4245

Edmund Y. Lam  —  Publications

All keywords:

| AI and deep learning | biomedical microscopy | compressed sensing | computational imaging | computational lithography | digital holography | education technology | electronic imaging | eye imaging | lensless imaging | light field | machine vision and automation | magnetic resonance imaging | metasurface | microplastics | neuromorphic imaging | optical coherence tomography | speckle | super-resolution |

Current keyword: biomedical microscopy

Academic Journals:

  1. Shuo Li, Mohamed Elgendi, Yanmin Zhu, Edmund Y. Lam, and Carlo Menon, “Lighting effects on optimal facial regions for remote heart rate measurement,” npj Cardiovascular Health, vol. 3, pp. 40(1–11), June 2026.
    DOI: 10.1038/s44325-026-00140-7

  2. Yunfei Tian, Shuo Li, Yanmin Zhu, Mohamed Elgendi, and Edmund Y. Lam, “Adaptive physiology-informed correction for reliable remote photoplethysmography heart-rate monitoring,” npj Digital Medicine, vol. 9, pp. 233(1–15), February 2026.
    DOI: 10.1038/s41746-026-02386-y

  3. Jiahao Liu, Xue Dong, Huaide Lu, Tao Liu, Wei Liu, Xinyao Hu, Quan Meng, Amin Jiang, Tao Jiang, Xiaohan Geng, Haosen Liu, Jun Cheng, Edmund Y. Lam, Yan-Jun Liu, Shan Tan, and Dong Li, “Bio-friendly and high-precision super-resolution imaging through self-supervised reconstruction structured illumination microscopy,” Nature Methods, vol. 23, pp. 395–404, February 2026.
    DOI: 10.1038/s41592-025-02966-y

  4. Thiel Lee, Evelyn H. Y. Cheung, Kelvin C. M. Lee, Dickson M. D. Siu, Michelle C. K. Lo, Edmund Y. Lam, Ruchi Goswami, Salvatore Girardo, Kyoohyun Kim, Felix Reichel, Marketa Kubankova, Martin Kräter, Jochen Guck and Kevin K. Tsia, “High-throughput multimodal optofluidic biophysical imaging cytometry,” Lab on a Chip, vol. 25, no. 20, pp. 5329–5341, October 2025.
    DOI: 10.1039/D5LC00381D

  5. Ni Chen, Yang Wu, Chao Tan, Liangcai Cao, Jun Wang, and Edmund Y. Lam, “Uncertainty-aware Fourier ptychography,” Light: Science and Applications, vol. 14, pp. 236(1–16), July 2025.
    DOI: 10.1038/s41377-025-01915-w

  6. Ni Chen, David J. Brady, and Edmund Y. Lam, “Differentiable imaging: Progress, challenges, and outlook,” Advanced Devices and Instrumentation, vol. 6, pp. 0117(1–17), July 2025.
    DOI: 10.34133/adi.0117

  7. Li Song, Kaiqiang Wang, Shuo Zhu, Zhenbo Ren, and Edmund Y. Lam, “Ptychographic image reconstruction with a phase-assisted alternating direction method of multipliers,” Optics Letters, vol. 50, no. 9, pp. 2816–2819, May 2025.
    DOI: 10.1364/OL.553571

  8. Shobana V. Stassen, Minato Kobashi, Edmund Y. Lam, Yuanhua Huang, Joshua W.K. Ho, and Kevin K. Tsia, “StaVia: Spatially and temporally aware cartography with higher order random walks for cell atlases,” Genome Biology, vol. 25, pp. 224(1–30), August 2024.
    DOI: 10.1186/s13059-024-03347-y

  9. Ziqi Zhang, Kelvin C.M. Lee, Dickson M.D. Siu, Michelle C.K. Lo, Queenie T.K. Lai, Edmund Y. Lam, and Kevin K. Tsia, “Morphological profiling by high-throughput single-cell biophysical fractometry,” Communications Biology, vol. 6, pp. 449(1–13), April 2023.
    DOI: 10.1038/s42003-023-04839-6

  10. Li Song and Edmund Y. Lam, “Phase retrieval with a dual recursive scheme,” Optics Express, vol. 31, no. 6, pp. 10386–10400, March 2023.
    DOI: 10.1364/OE.484649

  11. Boyi Huang, Jia Li, Bowen Yao, Zhigang Yang, Edmund Y. Lam, Jia Zhang, Wei Yan, and Junle Qu, “Enhancing image resolution of confocal fluorescence microscopy with deep learning,” PhotoniX, vol. 4, pp. 2(1–22), January 2023.
    DOI: 10.1186/s43074-022-00077-x
    Highlighted in the article ‘‘Microscopy's Cutting Edge'' in the April 2023 issue of Optics and Photonics News

  12. Zhou Ge, Haoyu Wei, Feng Xu, Yizhao Gao, Zhiqin Chu, Hayden K.-H. So, and Edmund Y. Lam, “Millisecond autofocusing microscopy using neuromorphic event sensing,” Optics and Lasers in Engineering, vol. 160, pp. 107247(1–9), January 2023.
    DOI: 10.1016/j.optlaseng.2022.107247

  13. Linpeng Lu, Jiaji Li, Yefeng Shu, Jiasong Sun, Jie Zhou, Edmund Y. Lam, Qian Chen, and Chao Zuo, “Hybrid brightfield and darkfield transport of intensity approach for high-throughput quantitative phase microscopy,” Advanced Photonics, vol. 4, no. 5, pp. 056002(1–12), September 2022.
    DOI: 10.1117/1.AP.4.5.056002

  14. Li Song and Edmund Y. Lam, “Iterative phase retrieval with a sensor mask,” Optics Express, vol. 30, no. 14, pp. 25788–25802, July 2022.
    DOI: 10.1364/OE.461367

  15. Li Song and Edmund Y. Lam, “Fast and robust phase retrieval for masked coherent diffractive imaging,” Photonics Research, vol. 10, no. 3, pp. 758–768, March 2022.
    DOI: 10.1364/PRJ.447862

  16. Zhenbo Ren, Peiyan Guan, Edmund Y. Lam, and Jianlin Zhao, “Extended focused imaging in microscopy using structure tensor and guided filtering,” Optics and Lasers in Engineering, vol. 140, pp. 106549(1–9), May 2021.
    DOI: 10.1016/j.optlaseng.2021.106549

  17. Ryan K.Y. Chan, Hongsen He, Yu-Xuan Ren, Cora S.W. Lai, Edmund Y. Lam, and Kenneth K. Y. Wong, “Axially resolved volumetric two-photon microscopy with an extended field of view using depth localization under mirrored Airy beams,” Optics Express, vol. 28, no. 26, pp. 39563–39573, December 2020.
    DOI: 10.1364/OE.412453

  18. Yulong Fan, Yunkun Xu, Meng Qiu, Wei Jin, Lei Zhang, Edmund Y. Lam, Din Ping Tsai, and Dangyuan Lei, “Phase-controlled metasurface design via optimized genetic algorithm,” Nanophotonics, vol. 9, no. 12, pp. 3931–3939, September 2020.
    DOI: 10.1515/nanoph-2020-0132

  19. Nan Meng, Edmund Y. Lam, Kevin K. Tsia, and Hayden K.-H. So, “Large-scale multi-class image-based cell classification with deep learning,” IEEE Journal of Biomedical and Health Informatics, vol. 23, no. 5, pp. 2091–2098, September 2019.
    DOI: 10.1109/JBHI.2018.2878878

  20. Runbin Shi, Justin S.J. Wong, Edmund Y. Lam, Kevin K. Tsia, and Hayden K.-H. So, “A real-time coprime line scan super-resolution system for ultra-fast microscopy,” IEEE Transactions on Biomedical Circuits and Systems, vol. 13, no. 4, pp. 781–792, August 2019.
    DOI: 10.1109/TBCAS.2019.2914946

  21. Ao Zhou, Wei Wang, Ni Chen, Edmund Y. Lam, Byoungho Lee, and Guohai Situ, “Fast and robust misalignment correction of Fourier ptychographic microscopy for full field of view reconstruction,” Optics Express, vol. 26, no. 18, pp. 23661–23674, September 2018.
    DOI: 10.1364/OE.26.023661

  22. Fenghua Shi, Meng Qiu, Lei Zhang, Edmund Y. Lam, and Dang Yuan Lei, “Multiplane illumination enabled by Fourier-transform metasurfaces for high-speed light-sheet microscopy,” ACS Photonics, vol. 5, no. 5, pp. 1676–1684, May 2018.
    DOI: 10.1021/acsphotonics.7b01457

  23. Antony C.S. Chan, Ho-Cheung Ng, Sharat C.V. Bogaraju, Hayden K.-H. So, Edmund Y. Lam, and Kevin K. Tsia, “All-passive pixel super-resolution of time-stretch imaging,” Scientific Reports, vol. 7, pp. 44608(1–11), March 2017.
    DOI: 10.1038/srep44608

  24. Jiang-Lai Wu, Yi-Qing Xu, Jing-Jiang Xu, Xiao-Ming Wei, Antony C.S. Chan, Anson H.L. Tang, Andy K.S. Lau, Bob M.F. Chung, Ho Cheung Shum, Edmund Y. Lam, Kenneth K.Y. Wong, and Kevin K. Tsia, “Ultrafast laser-scanning time-stretch imaging at visible wavelengths,” Light: Science and Applications, vol. 6, pp. e16196(1–10), January 2017.
    DOI: 10.1038/lsa.2016.196
    Highlighted in Nature Photonics

  25. Antony C.S. Chan, Andy K.S. Lau, Kenneth K.Y. Wong, Edmund Y. Lam, and Kevin K. Tsia, “Arbitrary two-dimensional spectrally encoded pattern generation — a new strategy for high-speed patterned illumination imaging,” Optica, vol. 2, no. 12, pp. 1037–1044, December 2015.
    DOI: 10.1364/OPTICA.2.001037

  26. Haiyan Ou, Chi Zhang, Xing Xu, Edmund Y. Lam, and Kenneth K.Y. Wong, “Chromatic-dispersion-free transmission using time-reversal optical parametric amplifier,” Electronics Letters, vol. 51, no. 4, pp. 347–349, February 2015.
    DOI: 10.1049/el.2014.4468

  27. Andy K.S. Lau, Terence T.W. Wong, Kenneth K.Y. Ho, Matthew T.H. Tang, Antony C.S. Chan, Xiaoming Wei, Edmund Y. Lam, Ho Cheung Shum, Kenneth K.Y. Wong, and Kevin K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular and tissue imaging at 1um,” Journal of Biomedical Optics, vol. 19, no. 7, pp. 076001(1–7), July 2014.
    DOI: 10.1117/1.JBO.19.7.076001

  28. Antony C.S. Chan, Terence T.W. Wong, Kenneth K.Y. Wong, Edmund Y. Lam, and Kevin K. Tsia, “Speed-dependent resolution analysis of ultrafast laser-scanning fluorescence microscopy,” Journal of the Optical Society of America B, vol. 31, no. 4, pp. 755–764, April 2014.
    DOI: 10.1364/JOSAB.31.000755

  29. Terence T.W. Wong, Andy K.S. Lau, Kenneth K.Y. Ho, Matthew Y.H. Tang, Joseph D.F. Robles, Xiaoming Wei, Antony C.S. Chan, Anson H.L. Tang, Edmund Y. Lam, Kenneth K.Y. Wong, Godfrey C.F. Chan, Ho Cheung Shum, and Kevin K. Tsia, “Asymmetric-detection time-stretch optical microscopy (ATOM) for ultrafast high-contrast cellular imaging in flow,” Scientific Reports, vol. 4, pp. 3656(1–9), January 2014.
    DOI: 10.1038/srep03656

Conference Proceedings:

  1. Meilu Zhu, Yuxing Li, Zhiwei Wang, and Edmund Y. Lam, “Personalized federated learning with residual Fisher information for medical image segmentation,” in IEEE International Symposium on Biomedical Imaging, pp. 1–4, April 2026.
    DOI: 10.1109/ISBI61048.2026.11515924

  2. Haosen Liu and Edmund Y. Lam, “Leveraging Fourier domain for unsupervised removal of structured noise in fluorescence microscopy imaging,” in IEEE International Symposium on Biomedical Imaging, pp. 1–4, April 2026.
    DOI: 10.1109/ISBI61048.2026.11515690

  3. Shuo Li, Mohamed Elgendi, Carlo Menon, Rosa H.M. Chan, and Edmund Y. Lam, “Gait-based soft biometric estimation using wearable inertial sensing: Comparative evaluation and demographic fairness analysis,” in IEEE Biomedical Circuits and Systems Conference, pp. 229–233, October 2025.
    DOI: 10.1109/BioCAS67066.2025.00058

  4. Yunfei Tian, Yunping Zhang, Yuxing Li, Shuo Zhu, and Edmund Y. Lam, “Self-supervised defocus blur kernel estimation with symmetry and smoothness constraints,” in Multimodal Sensing and Artificial Intelligence for Sustainable Future, volume 13570 of Proceedings of the SPIE, pp. 135700X, June 2025.
    DOI: 10.1117/12.3062402

  5. Ziqi Zhang, Kevin Tsia, Kelvin C.M. Lee, Dickson M. D. Siu, Michelle C. K. Lo, and Edmund Y. Lam, “High-throughput and high-resolution single-cell biophysical fractometry for functional cell morphological profiling,” in High-Speed Biomedical Imaging and Spectroscopy, volume PC12853 of Proceedings of the SPIE, pp. PC128530R, January 2024.
    DOI: 10.1117/12.3008474

  6. Yuqing Cao, Yuxing Li, Kai Hang Yiu, and Edmund Y. Lam, “Addressing healthcare needs of the elderly in contactless blood oxygen saturation estimation with rPPG,” in Computational Optical Imaging and Artificial Intelligence in Biomedical Sciences, volume 12857 of Proceedings of the SPIE, pp. 128570C, January 2024.
    DOI: 10.1117/12.3000619

  7. Li Song and Edmund Y. Lam, “Masked coherent diffractive imaging with ADMM-based phase retrieval,” in Biomedical Imaging and Sensing Conference, volume 12608 of Proceedings of the SPIE, pp. 126080B, April 2023.
    DOI: 10.1117/12.3007506

  8. Zhenbo Ren, Edmund Y. Lam, and Jianlin Zhao, “Learning-based cell detection in digital pathology,” in Conference on Lasers and Electro-Optics (CLEO), pp. JW1A.184, May 2021.
    DOI: 10.1364/CLEO_AT.2021.JW1A.184

  9. Li Song and Edmund Y. Lam, “Phase retrieval with data-driven dual alternating direction method of multipliers for coherent diffraction imaging,” in OSA Topical Meeting in Novel Techniques in Microscopy, pp. NTu1C.2, April 2021.
    DOI: 10.1364/NTM.2021.NTu1C.2

  10. Michelle C.K. Lo, Kelvin C.M. Lee, Dickson M.D. Siu, Edmund Y. Lam, and Kevin K. Tsia, “Augmented multiplexed asymmetric-detection time-stretch optical microscopy by generative deep learning,” in High-Speed Biomedical Imaging and Spectroscopy, volume 11654 of Proceedings of the SPIE, pp. 1165410, March 2021.
    DOI: 10.1117/12.2582985

  11. Jiqiang Kang, Cihang Kong, Pingping Feng, Can Li, Zhi-Chao Luo, Edmund Y. Lam, Kevin K. Tsia, and Kenneth K. Y. Wong, “Three-photon fluorescence microscopic imaging by a compact Er-doped fiber laser at 1.6 um,” in Conference on Lasers and Electro-Optics (CLEO), pp. SW4J.5, May 2018.
    DOI: 10.1364/CLEO_SI.2018.SW4J.5

  12. Edmund Y. Lam, “Computational ultrafast optical imaging for single-cell inspection and analysis,” in Intelligent Robotics and Industrial Applications using Computer Vision, January 2018.
    Invited Paper at the conference

  13. Edmund Y. Lam, Nan Meng, and Hayden K.H. So, “Deep convolutional neural network for single-cell image analysis,” in High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management, volume 10505 of Proceedings of the SPIE, pp. 105050K, January 2018.
    DOI: 10.1117/12.2295469

  14. Runbin Shi, Antony C.S. Chan, Edmund Y. Lam, and Hayden K.-H. So, “Image super-resolution for ultrafast optical time-stretch imaging,” in 24th Congress of the International Commission for Optics, pp. W1F-08, August 2017.

  15. Nan Meng, Hayden K.-H. So, and Edmund Y. Lam, “Computational single-cell classification using deep learning on bright-field and phase images,” in IAPR Conference on Machine Vision Applications, pp. 164–167, May 2017.

  16. Anson H.L. Tang, Antony C.S. Chan, Kelvin C.M. Lee, Edmund Y. Lam, Kenneth K.Y. Wong, and Kevin K. Tsia, “High-throughput time-stretch imaging cellular assay based on a DVD spinning platform,” in Real-time Photonic Measurements, Data Management, and Processing, volume 10026 of Proceedings of the SPIE, October 2016.

  17. Anson H.L. Tang, Antony C.S. Chan, P. Yeung, Barbara P. Chan, Edmund Y. Lam, Kenneth K.Y. Wong, and Kevin K. Tsia, “High-throughput time-stretch imaging cellular assay based on a high-speed spinning platform,” in IEEE Photonics Conference, pp. TuE2.2, October 2016.
    DOI: 10.1109/IPCon.2016.7831140

  18. Jianglai Wu, Yiqing Xu, Xiaoming Wei, Jingjiang Xu, Antony C.S. Chan, Edmund Y. Lam, Kenneth K. Wong, and Kevin K. Tsia, “Active, large-scale tuning of optical dispersion by free-space angular-chirp-enhanced delay (FACED),” in Conference on Lasers and Electro-Optics (CLEO), pp. SM4I.1, June 2016.
    DOI: 10.1364/CLEO_SI.2016.SM4I.1

  19. Antony C.S. Chan, Edmund Y. Lam, and Kevin K. Tsia, “Pixel super-resolution of time-stretch imaging by an equivalent-time sampling concept,” in High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management, volume 9720 of Proceedings of the SPIE, pp. 972004, February 2016.
    DOI: 10.1117/12.2212034
    PiPhotonics Best Paper Award

  20. Andy K.S. Lau, Anson H.L. Tang, Bob M.F. Chung, Kwok Yeung Tsang, Antony C.S. Chan, Xiaoming Wei, Kenneth K. Wong, Edmund Y. Lam, Kathryn S.E. Cheah, Anderson H.C. Shum, and Kevin K. Tsia, “Quantitative asymmetric-detection time-stretch optical microscopy (Q-ATOM) for ultrafast quantitative phase imaging flow cytometry,” in High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management, volume 9720 of Proceedings of the SPIE, pp. 97200Z, February 2016.
    DOI: 10.1117/12.2212116

  21. Antony Chan, Edmund Y. Lam, and Kevin K. Tsia, “Pixel super-resolution in optical time-stretch microscopy using acousto-optic deflector,” in OSA Topical Meeting in Bio-Optics: Design and Application, pp. BW2A.7, April 2015.
    DOI: 10.1364/BODA.2015.BW2A.7

  22. Anson H.L. Tang, Antony C.S. Chan, P. Yeung, Belle S.M. Kwok, Barbara P. Chan, Edmund Y. Lam, Kenneth K.Y. Wong, and Kevin K. Tsia, “High throughput cellular time-stretch imaging on a spinning planar platform,” in Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues, volume 9328 of Proceedings of the SPIE, February 2015.

  23. Antony C.S. Chan, Edmund Y. Lam, and Kevin K. Tsia, “Signal reduction in fluorescence imaging using radio frequency-multiplexed excitation by compressed sensing,” in Real-time Photonic Measurements, Data Management, and Processing, volume 9279 of Proceedings of the SPIE, pp. 92790U, October 2014.
    DOI: 10.1117/12.2072016

  24. Antony C.S. Chan, Andy K.S. Lau, Kenneth K.Y. Wong, Edmund Y. Lam, and Kevin K. Tsia, “Two-dimensional spectral-encoding for high speed arbitrary patterned illumination,” in Conference on Lasers and Electro-Optics (CLEO), pp. STh1H, June 2014.
    DOI: 10.1364/CLEO_SI.2014.STh1H.2

  25. Yiqing Xu, Xiaoming Wei, Antony C. Chan, Edmund Y. Lam, Kenneth Wong, and Kevin Tsia, “Optical time-stretch microscopy using Bessel spectral shower illumination,” in Conference on Lasers and Electro-Optics (CLEO), pp. ATu3P, June 2014.
    DOI: 10.1364/CLEO_AT.2014.ATu3P.6

  26. Antony C. Chan, Terence T.W. Wong, Kenneth K.Y. Wong, Edmund Y. Lam, and Kevin K. Tsia, “Revisit laser scanning fluorescence microscopy performance under fluorescence-lifetime-limited regime,” in Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues, volume 8947 of Proceedings of the SPIE, pp. 894726, February 2014.
    DOI: 10.1117/12.2038766

  27. Andy K.S. Lau, Terence T.W. Wong, Kenneth K.Y. Ho, Matthew Y.H. Tang, Joseph D.F. Robles, Xiaoming Wei, Antony C.S. Chan, Anson H.L. Tang, Edmund Y. Lam, Kenneth K.Y. Wong, Godfrey C.F. Chan, Ho Cheung Shum, and Kevin K. Tsia, “Ultrafast high-contrast microfluidic cellular imaging by asymmetric-detection time-stretch optical microscopy (ATOM),” in OSA Frontiers in Optics, pp. FW6A.7, October 2013.
    DOI: 10.1364/FIO.2013.FW6A.7
    Post-deadline Paper

  28. Andy K.S. Lau, Terence T.W. Wong, Antony C.S. Chan, Edmund Y. Lam, Kenneth K.Y. Wong, and Kevin K. Tsia, “Interferometric time-stretch microscopy for ultrafast quantitative cellular imaging at 1um,” in OSA Topical Meeting in Novel Techniques in Microscopy, pp. NW1B.4, April 2013.
    DOI: 10.1364/NTM.2013.NW1B.4

  29. Terence T.W. Wong, Matthew Y.H. Tang, Andy K.S. Lau, Antony C.S. Chan, Edmund Y. Lam, Kenneth K.Y. Wong, Anderson H.C. Shum, and Kevin K. Tsia, “Ultrafast flow imaging by 1um time-stretch microscopy,” in OSA Topical Meeting in Novel Techniques in Microscopy, pp. NW1B.5, April 2013.
    DOI: 10.1364/NTM.2013.NW1B.5

  30. Zhimin Xu and Edmund Y. Lam, “Hyperspectral reconstruction in biomedical imaging using terahertz systems,” in IEEE International Symposium on Circuits and Systems, pp. 2079–2082, May 2010.
    DOI: 10.1109/ISCAS.2010.5537219